Frequent monitoring of serum creatinine, with dose adjustment for changes in renal function, and adequate hydration is imperative. Foscavir is also indicated for the treatment of mucocutaneous herpes simplex virus. Foscarnet sodium is not recommended in patients undergoing hemodialysis because dosage guidelines have not been established. Proscar is not indicated for use in pediatric patients or women 5. Thank you for your interest in spreading the word on american journal of healthsystem pharmacy. The extent of inhibition varies with the enzyme isoform and with the regulatory input. Foscarnet also inhibited soluble and, to a lesser extent, particulate guanylyl cylase.
Foscarnet also exerts its antiviral effect on the viral. Foscarnet definition is a hydrated sodium salt na3co5p6h2o that is administered intravenously to individuals infected with hiv to treat retinitis caused by a cytomegalovirus. Foscarnet intravenous route proper use mayo clinic. Foscarnet by injection national library of medicine. Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Department of health and human services silver spring md 20993. Drug interactions associated with the use of ganciclovir and foscarnet sodium are. Not determined relevant identified uses of the substance or mixture and uses advised against intended use. Foscarnet injection comes as a liquid to be intravenously into a vein. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. Cidofovir has also be used intravitreally, although it is not approved for intraocular use. Foscarnet sodium injection foscavir side effects, medical. The combined use of intravitreal foscarnet and ganciclovir has also been reported. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt.
This medication is an antiviral that works by stopping the growth of viruses. Mar 07, 2015 this video shows you how to pronounce foscarnet. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2 foscarnet was approved for medical use in 1991. Foscarnet injection is used to treat symptoms of cytomegalovirus cmv infection of the eyes in patients with acquired immune deficiency syndrome aids. Fda approves foscarnet for hivrelated cmv retinitis, herpes. Frequent monitoring of serum creatinine, with dose adjustment for changes in renal function, and. If you have any further questions, ask your doctor or nurse. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Careful attention to dosing is required given the doserelated toxicities of foscarnet. Foscarnet is in a class of medications called antivirals. Nov 09, 2018 foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. After binding, the drug blocks the cleavage of the pyrophosphate moiety from deoxynucleotide triphosphates, in turn halting dna chain. Indeed, both the physicians desk reference and the drugs package insert specifically prohibit the intraocular use of this drug.
Foscavir foscarnet sodium dose, indications, adverse. The drug is potentially difficult and dangerous to use. Unlike interferon that exerts only short term effects,16 foscarnet sodium, which is a totally synthesized small molecule compound, functions at the. Foscarnet may also be used for other serious viral infections as determined by your doctor. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2. Ask your health care provider about possible side effects from foscarnet sodium. Foscarnet sodium definition of foscarnet sodium by. J1455 hcpcs code for injection, foscarnet sodium, per. This medicine is also used to treat herpes simplex virus hsv infections of the skin and. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Individually dispensed doses of foscarnet should be aseptically transferred and diluted with equal parts of 0. Foscarnet definition of foscarnet by the free dictionary.
Foscavir 24 mgml solution for infusion summary of product. Do not give other iv solution or drug through the same catheter with foscarnet. Foscarnet definition of foscarnet by merriamwebster. Antiviral therapies for herpesviruses clinical therapeutics. Foscavir has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. This medicine is also used to treat herpes simplex virus hsv infections of the skin and mucous membranes in people who are.
To help keep the amount constant, foscarnet must be given on a regular schedule. If the file has been modified from its original state, some details may not fully reflect the modified file. Foscarnet sodium is an antiviral medication that is fda approved for the treatment of cmv retinitis, mucocutaneous acyclovir resistant hsv infections. They have a broad spectrum of antiviral activity and are accordingly used for treatment of. Romain vial, christine zandotti, sophie alain, alexandre decourt, noemie jourdechiche, raj purgus, charleric bornet, laurent daniel, valerie moal, tristan legris 2017, brincidofovir use after foscarnet crystal nephropathy in a kidney transplant recipient with multiresistant cytomegalovirus infection, case reports in transplantation. Thus, foscarnet interferes with the generation of cyclic nucleotides, an effect which may give rise to clinical side effects. Cytoveneiv ganciclovir sodium for injection, for intravenous use. Controlling cmv retinitis can help decrease the risk of blindness from the infection. This medication is not a cure for cmv or hsv diseases. Foscarnet sodium is a congener of phosphonoacetic acid, and they are both the analogues of pyrophosphates. However, it does not work in treating certain viruses, such as the common cold or the flu. Foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. Foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids. Feb 21, 2019 foscarnet trisodium hexahydrate 24 mgml.
Stability of foscarnet sodium in 5% dextorse and 0. Foscavir foscarnet sodium this product information is intended only for residents of the united states. Foscarnet sodium definition of foscarnet sodium by the free. Foscavir foscarnet sodium injection product insert rubber latex has not been used in the manufacture of this device or drug container closure. For outlook, click inside of the body of an item, such as an email message or calendar event. J1455 hcpcs code for injection, foscarnet sodium, per mg. Foscarnet does not require activation phosphorylation by thymidine kinase or other kinases and therefore is active in vitro against hsv tk deficient mutants and cmv ul97 mutants.
Foscarnet phosphonomethanoic acid is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family. Store in accordance with information listed on the product insert. I want to embed the pdf file into the word document, so that it can be opened, and copied onto another location in its original form, not as a small picture of the original. Also, this medicine works best when there is a constant amount in the blood. This effect is increased when you also use certain other medicines, including. Glimepiride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus see.
This medication is also used to treat herpes infections hsv that do not respond to treatment with acyclovir acyclovirresistant. Refer to table below for recommended doses and adjust the dose as indicated. It binds reversibly near the pyrophosphatebinding site of dna polymerase or reverse transcriptase without requiring further modification 1. Even patients with serum creatinine in the normal range may require dose adjustment. Foscarnet side effects, dosage, interactions drugs. Foscarnet is used for the treatment of invasive cmv disease among patients with suspected or documented ganciclovirresistant cmv. This medicine is to be given only by or under the direct supervision of your doctor. In vivo micronucleus mouse positive rat oral ld 50 238277 mgkg in vitro cell transformation assay positive version. Continued ganciclovir valganciclovir foscarnet cidofovir hexadecyloxypropyl cidofovir. Pharmaceutical active used as antiviral details of the supplier of the safety data sheet 2. Women should not handle crushed or broken proscar tablets when they are pregnant or may potentially be pregnant due to potential risk to a male fetus 5. Information for the user foscavir 24 mgml solution for infusion foscarnet read all of this leaflet carefully before you start having this medicine because it contains important information for you. Do not use foscarnet sodium if the original seal over the container opening is broken or missing.
At this time, such toxicities are managed by dosage adjustments, temporary. Ganciclovir, foscarnet, and cidofovir are antiviral drugs approved for use against cytomegalovirus cmv in adults by the us food and drug administration. Keep foscarnet sodium in the container that it came in and keep the container tightly closed. Foscarnet will not cure cmv eye infection, but it may help to control worsening of the symptoms. Foscavir tm foscarnet sodium injection hospira inc. There is a black box warning for this drug as shown here. Jan 01, 2017 foscarnet may also be used for other serious viral infections as determined by your doctor. Careful personal hygiene is recommended after urination to lessen the potential for local irritation.
Foscarnet doses are based on renal function according to the adjusted cockroftgault equation. To ensure the best response, foscarnet must be given for the full time of treatment. Each ml of foscavir 24 mgml foscarnet sodium contains 240 micromoles 5. Foscarnet definition of foscarnet by medical dictionary. Foscavir foscarnet sodium injection side effects, images. Foscarnet should be discontinued at least 7 days prior to beginning cidofovir. Foscarnet, phosphonoformic acid 8, is a potent and broadspectrum antiherpes agent ic 50 0. It is usually infused slowly over 1 to 2 hours every 8 or 12 hours. Guidelines for pediatric dosage and administration have not been formally. Major when possible, avoid concurrent use of foscarnet with other drugs known to prolong the qt interval, such as ciprofloxacin. Because this medication is used in patients who use other medications, it is difficult to tell which side effects are caused by foscarnet. Foscavir injection, phosphonoformic acid foscarnet dosing.
Pdf foscarnet is an important antiviral medication used mainly in the treatment of complicated herpessimplex. Allowance must be made for the sodium content of foscarnet and its diluent in the total daily sodium intake of the patient. Due to sodium content of foscarnet 240 micromoles 5. Foscavir injection, phosphonoformic acid foscarnet. However, instead of getting a pdf icon to click on in order to open the pdf file, i get a small copy of the pdf file. Foscarnet sodium definition of foscarnet sodium by the. Ask your health care provider if there are interactions between foscarnet sodium and the other medicines you take.
Highlights of prescribing information these highlights. This medication is used to control cytomegalovirus cmv eye infections cmv retinitis in persons with aids. Foscarnet fda prescribing information, side effects and uses. The length of your treatment depends on how you respond to the medication. The retinal toxicity of single and repeated intravitreal injections of foscarnet was investigated. The most common 10% nonhematologic adverse drug reactions were rash, pruritis, headache, nausea, fatigue, alopecia, myalgia, and upper abdominal pain. An antiviral drug, cna3o5p, used intravenously to treat herpesvirus infections, especially cytomegalovirus retinitis. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. Foscarnet sodium has a boxed warning regarding kidney toxicity. Cardiovascular risk associated with rapid infusion rates see full prescribing information for complete boxed warning the rate of intravenous cerebyx administration should not exceed 150 mg phenytoin sodium equivalents pe per minute in adults and 2 mg pekgmin or 150 mg pemin, whichever is slower in pediatric patients because of the risk of severe hypotension and cardiac. Buy foscavir foscarnet sodium online blink health rx.
Valacyclovir, famciclovir, brivudin, and foscarnet can be used depending on the patients clinical and metabolic status 3. Foscarnet is sometimes combined with another antiviral drug, ganciclovir, when the cmv infection does not respond to either drug used alone for treatment. Unlike interferon that exerts only short term effects,16 foscarnet sodium, which is a totally synthesized small molecule compound, functions at the pyrophosphate binding site of viral dna polymerase. Nausea, vomiting, headache, diarrhea, dizziness, loss of appetite, and increased sweating have been reported. Foscarnet is usually given for hsv after other antiviral medications have.
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na 3 co 5 p6 h 2 o and a molecur weight of 300. Definition of foscarnet from the collins english dictionary. Proscar may increase the risk of highgrade prostate cancer 5. Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus cmv and herpes simplex virus types 1 and 2 hsv1 and hsv2. Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. This site complies with the honcode standard for trustworthy health information. Foscarnet definition and meaning collins english dictionary. Foscarnet sodium definition of foscarnet sodium by medical. When peripheral veins are used, the solution of foscarnet 24 mgml must be diluted.
Foscavir is indicated for induction and maintenance therapy of cytomegalovirus cmv retinitis in patients with aids. Foscarnet sodium dosing must be individualized according to the patients renal function status. You may receive foscarnet injection in a hospital or you may administer the medication at home. For peripheral infusion, dilute to 12 mgml with d5w or ns. M for hsv1, hsv2, hcmv, and ebv and is used in the clinic for the treatment of hcmv infection.
Foscarnet intravenous route description and brand names. Mar, 2017 what other drugs will affect foscarnet foscavir. Foscarnet trisodium phosphonoformate is a pyrophosphate analog. Cardiovascular risk associated with rapid infusion rates see full prescribing information for complete boxed warning the rate of intravenous cerebyx administration should not exceed 150 mg phenytoin sodium equivalents pe per minute in adults and 2 mg pekgmin or 150 mg pemin, whichever is slower in pediatric patients because of the risk of severe hypotension and. It is classified as a pyrophosphate analog dna polymerase inhibitor. Foscarnet is usually given for hsv after other antiviral medications have been tried without successful treatment. Toxicologic and pharmacokinetic analysis of intravitreal. Common adverse reactions include fever, nausea, diarrhea, anemia, abdominal pain,hypokalemia, coughing, dyspnea,confusion, anxiety. Welcome to the leading independent provider of fda approved medication information, delivering the latest package inserts and product labels directly from the fda repository in an easytoread format. Drug interactions and toxicities associated with the antiviral. Foscarnet injection is also used to treat herpes simplex virus hsv infections of the skin and mucus membranes mouth, anus in people whose immune system is not working normally and when treatment with acyclovir did not help. Read all of this leaflet carefully before you start. Jan 10, 2019 foscarnet sodium may affect the way other medicines or products work, and other medicines or products may affect how foscarnet sodium works. Injection, foscarnet sodium, per mg drugs administered other than oral method, chemotherapy drugs j1455 is a valid 2020 hcpcs code for injection, foscarnet sodium, per mg or just foscarnet sodium injection for short, used in medical care.